Overview

Location [1]
21q21.3
Protein [2]
C31
Synonyms [1]
APPI, CTFgamma, AD1, preA4, AAA, PN2, PN-II, ABETA, ABPP, CVAP

APP is altered in 0.39% of all cancers with breast invasive ductal carcinoma, adenocarcinoma of unknown primary, invasive breast carcinoma, bladder urothelial carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

APP GENIE Cases - Top Diseases

The most common alteration in APP is APP-NRG1 Fusion (0.39%) [3].

APP GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.