Biomarkers /

AURKC

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Overview

Location [1]
19q13.43
Protein [2]
Aurora kinase C
Synonyms [1]
AIE2, STK13, AIK3, AurC, SPGF5, ARK3, HEL-S-90, aurora-C

AURKC is altered in 0.72% of all cancers with endometrial endometrioid adenocarcinoma, cervical squamous cell carcinoma, colorectal adenocarcinoma, high grade ovarian serous adenocarcinoma, and low grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

AURKC GENIE Cases - Top Diseases

The most common alterations in AURKC are AURKC Mutation (0.72%), AURKC E148Q (0.77%), AURKC Q78E (0.77%), AURKC S65N (0.77%), and AURKC A151S (0.39%) [3].

AURKC GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.