Location [1]
Protein [2]
Bcl-2-binding component 3
Synonyms [1]

BBC3 is altered in 0.50% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, conventional glioblastoma multiforme, lung adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

BBC3 GENIE Cases - Top Diseases

The most common alterations in BBC3 are BBC3 Loss (0.11%), BBC3 Amplification (0.05%), BBC3 R223Q (0.01%), BBC3 X126_splice (0.01%), and BBC3 A254T (0.01%) [3].

BBC3 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.