Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
9q34.2
Protein [2]
Bromodomain-containing protein 3
Synonyms [1]
ORFX, RING3L

BRD3 is altered in 2.23% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

BRD3 GENIE Cases - Top Diseases

The most common alterations in BRD3 are BRD3 A273T (0.11%), BRD3 T189P (1.63%), BRD3 P194S (0.06%), BRD3 R441H (0.07%), and BRD3 E496_K500del (0.04%) [3].

BRD3 GENIE Cases - Top Alterations

Significance of BRD3 in Diseases

Lymphoma +

Malignant Solid Tumor +

Central Nervous System Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.