Overview

Location [1]
1q24.2
Protein [2]
T-cell surface glycoprotein CD3 zeta chain
Synonyms [1]
TCRZ, T3Z, CD3Z, CD3Q, CD3H, IMD25, CD3-ZETA

CD247 is altered in 0.01% of all cancers with glioblastoma and undifferentiated pleomorphic sarcoma having the greatest prevalence of alterations [3].

CD247 GENIE Cases - Top Diseases

The most common alterations in CD247 are CD247-DDR2 Fusion (0.00%) and CD247-NTRK1 Fusion (0.02%) [3].

CD247 GENIE Cases - Top Alterations

Significance of CD247 in Diseases

Acute Lymphoblastic Leukemia +

Enteropathy-Associated T-Cell Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.