Overview

Location [1]
16q22.1
Protein [2]
Cadherin-3
Synonyms [1]
PCAD, HJMD, CDHP

CDH3 is altered in 0.01% of all cancers with adenocarcinoma of unknown primary, colon adenocarcinoma, colorectal adenocarcinoma, gastric adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

CDH3 GENIE Cases - Top Diseases

The most common alterations in CDH3 are CDH3-CBFB Fusion (0.00%), CDH3-FGFR2 Fusion (0.01%), and CDH3-KDM6B Fusion (0.01%) [3].

CDH3 GENIE Cases - Top Alterations

Significance of CDH3 in Diseases

Breast Carcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Head And Neck Carcinoma +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.