Overview

Location [1]
12q14.1
Pathway
Cell cycle control
Protein [2]
Cyclin-dependent kinase 4
Synonyms [1]
CMM3, PSK-J3

Cyclin-dependent kinase 4 (CDK4) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the progression of the cell cycle at from G1 to S phase and the activation of RB1. Missense and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

CDK4 is altered in 2.17% of all cancers with lung adenocarcinoma, dedifferentiated liposarcoma, conventional glioblastoma multiforme, glioblastoma, and well differentiated liposarcoma having the greatest prevalence of alterations [3].

CDK4 GENIE Cases - Top Diseases

The most common alterations in CDK4 are CDK4 Amplification (1.95%), CDK4 Mutation (0.41%), CDK4 Fusion (0.08%), CDK4 R24L (0.04%), and CDK4 Loss (0.03%) [3].

CDK4 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of CDK4 in Diseases

Liposarcoma +

Malignant Solid Tumor +

Breast Carcinoma +

Malignant Glioma +

Soft Tissue Sarcoma +

Colorectal Carcinoma +

Multiple Myeloma +

Osteosarcoma +

Non-Small Cell Lung Carcinoma +

Melanoma +

Head And Neck Squamous Cell Carcinoma +

Ovarian Carcinoma +

Non-Hodgkin Lymphoma +

Acral Lentiginous Melanoma +

Glioblastoma +

Primary Peritoneal Carcinoma +

Gallbladder Carcinoma +

Lung Adenocarcinoma +

Lung Carcinoma +

Chondrosarcoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Fallopian Tube Carcinoma +

Cancer +

Endometrial Endometrioid Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Malignant Uterine Neoplasm +

Squamous Cell Lung Carcinoma +

Esophageal Carcinoma +

Pancreatic Carcinoma +

Bladder Carcinoma +

Germ Cell Tumor +

Head And Neck Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Ovarian Epithelial Tumor +

Bile Duct Carcinoma +

Cholangiocarcinoma +

Cervical Carcinoma +

Prostate Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Lymphoma +

Mesothelioma +

Clear Cell Renal Cell Carcinoma +

Bronchogenic Carcinoma +

Chordoma +

Dedifferentiated Chondrosarcoma +

Esophageal Squamous Cell Carcinoma +

Meningioma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.