Overview

Caudal type homeobox 2 (CDX2) is a gene that encodes a transcription factor protein that regulates intestine specific genes involved in cell growth and differentiation. The protein is also involved in embryonic development of the intestinal tract. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CDX2 is altered in 0.09% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, appendix adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.