Biomarkers /

CRTC2

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Overview

Location [1]
1q21.3
Protein [2]
CREB-regulated transcription coactivator 2
Synonyms [1]
TORC2, TORC-2

CRTC2 is altered in 1.40% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, invasive breast carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

CRTC2 GENIE Cases - Top Diseases

The most common alterations in CRTC2 are CRTC2 Mutation (1.18%), CRTC2 Amplification (0.09%), CRTC2 A439V (0.02%), CRTC2 G304S (0.02%), and CRTC2 G521S (0.02%) [3].

CRTC2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.