Biomarkers /

CYP2D6

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Overview

Location [1]
22q13.2
Protein [2]
Cytochrome P450 2D6
Synonyms [1]
CPD6, CYP2D8P2, CYP2D7BP, P450-DB1, P450DB1, P450C2D, CYPIID6, CYP2D, CYP2D7AP, CYP2D7P2, CYP2DL1

CYP2D6 is altered in 2.44% of all cancers with endometrial endometrioid adenocarcinoma, low grade ovarian serous adenocarcinoma, breast invasive ductal carcinoma, cervical squamous cell carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

CYP2D6 GENIE Cases - Top Diseases

The most common alterations in CYP2D6 are CYP2D6 K281del (10.71%), CYP2D6 E410K (0.39%), CYP2D6 A163T (0.22%), CYP2D6 A165T (0.22%), and CYP2D6 A235V (0.85%) [3].

CYP2D6 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.