DKC1 is altered in 0.90% of all cancers with lung adenocarcinoma, endometrial endometrioid adenocarcinoma, invasive breast carcinoma, breast invasive ductal carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in DKC1 are DKC1 Mutation (0.77%), DKC1 Amplification (0.10%), DKC1 D359N (0.02%), DKC1 G361S (0.03%), and DKC1 G383V (0.09%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.