Associated Genetic Biomarkers
Dual specificity phosphatase 4 (DUSP4) is a gene that encodes a protein that belongs to the dual specificity protein phosphatase subfamily. The protein functions in the negative regulation of members of the mitogen-activated protein kinase family. The inactivation of these kinases is achieved by dephosphorylation. Fusions, missense mutations, silent mutations, nonstop extensions, and frameshift insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
DUSP4 is altered in 1.79% of all cancers with colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, breast invasive ductal carcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in DUSP4 are DUSP4 Loss (1.30%), DUSP4 Amplification (0.14%), DUSP4 E304K (0.01%), DUSP4 H34Q (0.28%), and DUSP4 P168S (0.01%) .
DUSP4 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains DUSP4 status as an inclusion criterion, 1 is phase 2 (0 open).
Trials with DUSP4 status in the inclusion eligibility criteria most commonly target adenocarcinoma of the gastroesophageal junction and gastric adenocarcinoma .
The most frequent alteration to serve as an inclusion eligibility criterion is DUSP4 Expression .
Docetaxel and selumetinib are the most frequent therapies in trials with DUSP4 as an inclusion criteria .
Significance of DUSP4 in Diseases
Adenocarcinoma Of The Gastroesophageal Junction +
DUSP4 is altered in 1.56% of adenocarcinoma of the gastroesophageal junction patients .
DUSP4 is an inclusion criterion in 1 clinical trial for adenocarcinoma of the gastroesophageal junction, of which 0 are open and 1 is closed. Of the trial that contains DUSP4 status and adenocarcinoma of the gastroesophageal junction as inclusion criteria, 1 is phase 2 (0 open) .
Gastric Adenocarcinoma +
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.