Overview

Location [1]
4q35.2
Protein [2]
Double homeobox protein 4
Synonyms [1]
DUX4L

DUX4 is altered in 0.05% of all cancers with round cell sarcoma, follicular lymphoma, high-grade neuroepithelial tumor, NOS, mature B-cell neoplasm, and multiple myeloma having the greatest prevalence of alterations [3].

DUX4 GENIE Cases - Top Diseases

The most common alterations in DUX4 are DUX4-IGH Fusion (0.10%) and DUX4-CIC Fusion (0.01%) [3].

DUX4 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.