Location [1]
Protein [2]
ETS-related transcription factor Elf-4
Synonyms [1]

E74-like factor 4 (ets domain transcription factor) (ELF4) is a gene that encodes a protein that functions as a transcriptional activator. The protein binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

ELF4 is altered in 0.03% of all cancers with prostate adenocarcinoma, anal squamous cell carcinoma, angiosarcoma, clear cell renal cell carcinoma, and dedifferentiated liposarcoma having the greatest prevalence of alterations [3].

ELF4 GENIE Cases - Top Diseases

The most common alteration in ELF4 is ELF4-ERG Fusion (0.02%) [3].

ELF4 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.