EPH receptor A5 (EPHA5) is a gene that encodes a protein-tyrosine kinase in the ephrin receptor family. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
EPHA5 is altered in 2.91% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and squamous cell lung carcinoma having the greatest prevalence of alterations .
The most common alterations in EPHA5 are EPHA5 Mutation (2.94%), EPHA5 Amplification (0.12%), EPHA5 Loss (0.12%), EPHA5 E665K (0.04%), and EPHA5 R896H (0.03%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.