Location [1]
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Ephrin type-A receptor 5
Synonyms [1]

EPH receptor A5 (EPHA5) is a gene that encodes a protein-tyrosine kinase in the ephrin receptor family. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

EPHA5 is altered in 2.91% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and squamous cell lung carcinoma having the greatest prevalence of alterations [3].

EPHA5 GENIE Cases - Top Diseases

The most common alterations in EPHA5 are EPHA5 Mutation (2.94%), EPHA5 Amplification (0.12%), EPHA5 Loss (0.12%), EPHA5 E665K (0.04%), and EPHA5 R896H (0.03%) [3].

EPHA5 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.