ERBB receptor feedback inhibitor 1 (ERFFI1) is a gene that encodes a protein that functions as a negative regulator of several EGFR family members by inhibiting EGFR catalytic activity and autophosphorylation. The protein also regulates responses to steroid hormones in the uterus. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as bone cancer, liver cancer, and skin cancer.
ERRFI1 is altered in 0.94% of all cancers with conventional glioblastoma multiforme, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations .
The most common alterations in ERRFI1 are ERRFI1 Loss (0.22%), ERRFI1 Amplification (0.11%), ERRFI1 E323* (0.02%), ERRFI1 R244Q (0.01%), and ERRFI1 R331H (0.03%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.