Location [1]
Protein [2]
Protein C-ets-1
Synonyms [1]
c-ets-1, EWSR2, ETS-1, p54

V-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1) is a gene that encodes a transcription factor protein that functions as either a transcriptional activator or repressor of multiple genes. The protein is also plays a role in stem cell development, cell senescence and death, and tumorigenesis. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and pleural cancer.

ETS1 is altered in 0.80% of all cancers with adenocarcinoma of unknown primary, melanoma, anaplastic oligodendroglioma, basal cell carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

ETS1 GENIE Cases - Top Diseases

The most common alterations in ETS1 are ETS1 A51T (0.07%), ETS1 Amplification (2.04%), ETS1 D234G (0.09%), ETS1 D313N (0.07%), and ETS1 E130D (1.09%) [3].

ETS1 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.