Associated Genetic Biomarkers
ETS variant 5 (ETV5) is a gene that encodes a transcription factor protein that is a member of the ETS (E twenty-six) family. The protein binds to DNA containing sequences that contain the nucleotide sequence GGAA. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and urinary tract cancer.
ETV5 is altered in 0.61% of all cancers with lung adenocarcinoma, prostate adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and squamous cell lung carcinoma having the greatest prevalence of alterations .
The most common alterations in ETV5 are ETV5 Amplification (0.22%), ETV5 P152Q (0.07%), ETV5 E323K (0.04%), ETV5 Fusion (0.04%), and ETV5 R498H (0.03%) .
ETV5 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains ETV5 status as an inclusion criterion, 1 is phase 2 (0 open).
Trials with ETV5 status in the inclusion eligibility criteria most commonly target adenocarcinoma of the gastroesophageal junction and gastric adenocarcinoma .
The most frequent alteration to serve as an inclusion eligibility criterion is ETV5 Expression .
Docetaxel and selumetinib are the most frequent therapies in trials with ETV5 as an inclusion criteria .
Significance of ETV5 in Diseases
Adenocarcinoma Of The Gastroesophageal Junction +
ETV5 is an inclusion criterion in 1 clinical trial for adenocarcinoma of the gastroesophageal junction, of which 0 are open and 1 is closed. Of the trial that contains ETV5 status and adenocarcinoma of the gastroesophageal junction as inclusion criteria, 1 is phase 2 (0 open) .
Gastric Adenocarcinoma +
ETV5 is an inclusion criterion in 1 clinical trial for gastric adenocarcinoma, of which 0 are open and 1 is closed. Of the trial that contains ETV5 status and gastric adenocarcinoma as inclusion criteria, 1 is phase 2 (0 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.