Overview

Location [1]
17q21.2
Protein [2]
Histone-lysine N-methyltransferase EZH1
Synonyms [1]
KMT6B

EZH1 is altered in 0.86% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

EZH1 GENIE Cases - Top Diseases

The most common alterations in EZH1 are EZH1 Mutation (0.69%), EZH1 Loss (0.06%), EZH1 Amplification (0.05%), EZH1 R557C (0.02%), and EZH1 G624R (0.01%) [3].

EZH1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.