Biomarkers /

FAT3

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Overview

Location [1]
11q14.3
Protein [2]
Protocadherin Fat 3
Synonyms [1]
CDHR10, CDHF15, hFat3

FAT3 is altered in 0.73% of all cancers with conventional glioblastoma multiforme, melanoma, cutaneous melanoma, skin squamous cell carcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

FAT3 GENIE Cases - Top Diseases

The most common alterations in FAT3 are FAT3 D3797N (0.11%), FAT3 E120K (0.11%), FAT3 V4534M (0.11%), FAT3 D292N (0.08%), and FAT3 D604N (0.08%) [3].

FAT3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.