Overview

Location [1]
10q24.32
Protein [2]
Fibroblast growth factor 8
Synonyms [1]
AIGF, FGF-8, HBGF-8, KAL6, HH6

FGF8 is altered in 0.01% of all cancers with dedifferentiated liposarcoma, endometrial carcinoma, and parathyroid gland carcinoma having the greatest prevalence of alterations [3].

FGF8 GENIE Cases - Top Diseases

The most common alterations in FGF8 are FGF8 Mutation (0.52%), FGF8 L18I (0.26%), and FGF8 P46A (0.26%) [3].

FGF8 GENIE Cases - Top Alterations

Significance of FGF8 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Endometrial Carcinoma +

Cancer +

Anaplastic Astrocytoma +

Anaplastic Oligodendroglioma +

Cholangiocarcinoma +

Extrahepatic Cholangiocarcinoma +

Gastric Carcinoma +

Glioblastoma +

Intrahepatic Cholangiocarcinoma +

Myeloproliferative Neoplasm +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.