Location [1]
Protein [2]
Friend leukemia integration 1 transcription factor
Synonyms [1]

Fli-1 proto-oncogene, ETS transcription factor (FLI1) is a gene that encodes a protein that functions as an ETS DNA-binding domain containing transcription factor. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, parathyroid cancer, and skin cancer.

FLI1 is altered in 0.26% of all cancers with Ewing sarcoma, lung adenocarcinoma, prostate adenocarcinoma, sarcoma, NOS, and soft tissue neoplasm having the greatest prevalence of alterations [3].

FLI1 GENIE Cases - Top Diseases

The most common alterations in FLI1 are FLI1-EWSR1 Fusion (0.19%), FLI1 S89N (0.28%), FLI1 A25G (0.22%), FLI1 A297T (12.50%), and FLI1 D14N (0.26%) [3].

FLI1 GENIE Cases - Top Alterations

Significance of FLI1 in Diseases

Ewing Sarcoma +

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.