Overview

Location [1]
5q35.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Vascular endothelial growth factor receptor 3
Synonyms [1]
VEGFR3, LMPHM1, FLT-4, FLT41, LMPH1A, VEGFR-3, CHTD7, PCL

Fms-related tyrosine kinase 4 (FLT4) is a gene that encodes a protein that is a receptor tyrosine kinase in the vascular endothelial growth factor receptor (VEGF) family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

FLT4 is altered in 3.05% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

FLT4 GENIE Cases - Top Diseases

The most common alterations in FLT4 are FLT4 Mutation (2.58%), FLT4 Missense (2.48%), FLT4 Loss (0.14%), FLT4 Nonsense (0.12%), and FLT4 Amplification (0.12%) [3].

FLT4 GENIE Cases - Top Alterations

Significance of FLT4 in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Carcinoma +

Melanoma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Esophageal Squamous Cell Carcinoma +

Malignant Uterine Neoplasm +

Colorectal Carcinoma +

Lung Carcinoma +

Malignant Laryngeal Neoplasm +

Esophageal Carcinoma +

Multiple Myeloma +

Cancer +

Head And Neck Carcinoma +

Oropharyngeal Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Lip And Oral Cavity Carcinoma +

Nasopharyngeal Carcinoma +

Cervical Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Bile Duct Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Soft Tissue Sarcoma +

Malignant Salivary Gland Neoplasm +

Gallbladder Carcinoma +

Prostate Carcinoma +

Gastrointestinal Stromal Tumor +

Bronchogenic Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.