Location [1]
Protein [2]
Forkhead box protein L2
Synonyms [1]

Forkhead box L2 (FOXL2) is a gene that encodes a forkhead transcription factor protein that functions in ovarian development and function. Missense and silent mutations are observed in cancers such as cervical cancer, ovarian cancer, and testicular cancer.

FOXL2 is altered in 1.08% of all cancers with lung adenocarcinoma, ovarian granulosa cell tumor, colon adenocarcinoma, prostate adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

FOXL2 GENIE Cases - Top Diseases

The most common alterations in FOXL2 are FOXL2 Mutation (0.81%), FOXL2 Amplification (0.22%), FOXL2 C134W (0.12%), FOXL2 P212A (0.16%), and FOXL2 E118K (0.04%) [3].

FOXL2 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.