Overview

Location [1]
6q22.1
Protein [2]
Tyrosine-protein kinase FRK
Synonyms [1]
RAK, GTK, PTK5

FRK is altered in 0.09% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, appendix adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

FRK GENIE Cases - Top Diseases

Significance of FRK in Diseases

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Non-Small Cell Lung Carcinoma +

Oropharyngeal Carcinoma +

Pancreatic Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.