Overview

Location [1]
16p13.3
Protein [2]
Zinc finger protein GLIS2
Synonyms [1]
NKL, NPHP7

GLIS2 is altered in 0.08% of all cancers with appendix mucinous adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, colorectal adenocarcinoma, and esophageal adenocarcinoma having the greatest prevalence of alterations [3].

GLIS2 GENIE Cases - Top Diseases

Significance of GLIS2 in Diseases

Acute Biphenotypic Leukemia +

Acute Erythroid Leukemia +

Acute Lymphoblastic Leukemia +

Acute Megakaryoblastic Leukemia +

Acute Myeloid Leukemia +

Acute Undifferentiated Leukemia +

Chronic Myeloid Leukemia +

Hodgkin Lymphoma +

Juvenile Myelomonocytic Leukemia +

Myelodysplastic Syndromes +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Non-Hodgkin Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.