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GNB1

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Associated Diseases

Overview

Location [1]
1p36.33
Protein [2]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Synonyms [1]
MDS, MRD42

GNB1 is altered in 0.13% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, follicular lymphoma, myeloproliferative neoplasm, unknown, and B-cell lymphoblastic leukemia/lymphoma having the greatest prevalence of alterations [3].

GNB1 GENIE Cases - Top Diseases

The most common alterations in GNB1 are GNB1 Loss (0.38%), GNB1 K57N (0.12%), GNB1 G116S (0.07%), GNB1 K89E (0.07%), and GNB1 Amplification (0.05%) [3].

GNB1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.