Location [1]
Protein [2]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Synonyms [1]

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HERPUD1) is a gene that encodes a protein that functions in the unfolded protein response (UPR) and ER-associated protein degradation system (ERAD) - both of which are components of the endoplasmic reticulum stress response. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

HERPUD1 is altered in 0.08% of all cancers with prostate adenocarcinoma, low-grade glioma, NOS, pancreatic adenocarcinoma, pilocytic astrocytoma, and thyroid gland papillary carcinoma having the greatest prevalence of alterations [3].

HERPUD1 GENIE Cases - Top Diseases

The most common alterations in HERPUD1 are HERPUD1-BRAF Fusion (0.14%) and HERPUD1-ERG Fusion (0.02%) [3].

HERPUD1 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.