Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Hepatic leukemia factor
Synonyms [1]

Hepatic leukemia factor (HLF) is a gene that encodes a protein that functions as a transcriptional activator. Fusions, missense mutations, silent mutations are observed in cancers such as intestinal cancer and ovarian cancer.

HLF is altered in 0.10% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, endometrial serous adenocarcinoma, and esophageal adenocarcinoma having the greatest prevalence of alterations [3].

HLF GENIE Cases - Top Diseases

The most common alterations in HLF are HLF A254T (0.22%), HLF E2Q (0.39%), HLF M86I (0.22%), HLF R275S (0.39%), and HLF R6Q (0.22%) [3].

HLF GENIE Cases - Top Alterations

Significance of HLF in Diseases

B-Cell Acute Lymphoblastic Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.