Location [1]
Protein [2]
Heat shock protein HSP 90-alpha
Synonyms [1]
LAP-2, HSPN, Hsp90, HSPC1, Hsp103, LAP2, Hsp89, HSPCAL4, HSP86, HSPCA, HSP89A, EL52, HEL-S-65p, HSP90A, HSP90N, HSPCAL1

Heat shock protein 90 kDa alpha (cytosolic), class A member 1 (HSP90AA1) is a gene that encodes a protein that functions as a molecular chaperone. The protein aids in the proper folding of target proteins by utilizing ATPase activity. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

HSP90AA1 is altered in 2.12% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, prostate adenocarcinoma, colon adenocarcinoma, and glioblastoma having the greatest prevalence of alterations [3].

HSP90AA1 GENIE Cases - Top Diseases

The most common alterations in HSP90AA1 are HSP90AA1 Mutation (1.77%), HSP90AA1 K279del (0.22%), HSP90AA1 Amplification (0.31%), HSP90AA1 K241E (0.15%), and HSP90AA1 P11L (0.12%) [3].

HSP90AA1 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.