Location [1]
Protein [2]
Endoplasmic reticulum chaperone BiP
Synonyms [1]
GRP78, BIP, HEL-S-89n

HSPA5 is altered in 0.99% of all cancers with conventional glioblastoma multiforme, cutaneous melanoma, neuroendocrine carcinoma, NOS, anaplastic oligodendroglioma, and atypical myeloid disorder having the greatest prevalence of alterations [3].

HSPA5 GENIE Cases - Top Diseases

The most common alterations in HSPA5 are HSPA5 A208D (0.07%), HSPA5 A325T (0.09%), HSPA5 A8S (0.09%), HSPA5 D238V (0.07%), and HSPA5 D615V (0.09%) [3].

HSPA5 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.