Biomarkers /

ID4

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Associated Diseases

Overview

Location [1]
6p22.3
Protein [2]
DNA-binding protein inhibitor ID-4
Synonyms [1]
bHLHb27, IDB4

ID4 is altered in 0.75% of all cancers with bladder urothelial carcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, glioblastoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

ID4 GENIE Cases - Top Diseases

The most common alterations in ID4 are ID4 Amplification (0.22%), ID4 A47_A48dup (0.08%), ID4 Loss (0.06%), ID4 A39T (0.03%), and ID4 A47_A48del (0.03%) [3].

ID4 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.