Overview

Location [1]
8p11.21
Protein [2]
Inhibitor of nuclear factor kappa-B kinase subunit beta
Synonyms [1]
IMD15A, IMD15B, IMD15, NFKBIKB, IKK-beta, IKKB, IKK2

IKBKB is altered in 1.48% of all cancers with bladder urothelial carcinoma, cervical squamous cell carcinoma, high grade ovarian serous adenocarcinoma, melanoma, and anaplastic astrocytoma having the greatest prevalence of alterations [3].

IKBKB GENIE Cases - Top Diseases

The most common alterations in IKBKB are IKBKB Mutation (1.48%), IKBKB A270G (0.22%), IKBKB A422P (0.22%), IKBKB A95S (0.20%), and IKBKB D562N (0.20%) [3].

IKBKB GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.