Location [1]
Protein [2]
Insulin receptor substrate 1
Synonyms [1]

Insulin receptor substrate 1 (IRS1) is a gene that encodes a protein that is phosphorylated by insulin receptor tyrosine kinase. The protein is important for insulin regulation. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and stomach cancer.

IRS1 is altered in 1.78% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

IRS1 GENIE Cases - Top Diseases

The most common alterations in IRS1 are IRS1 Mutation (1.45%), IRS1 Loss (0.07%), IRS1 Amplification (0.05%), IRS1 E37K (0.03%), and IRS1 K52del (0.02%) [3].

IRS1 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.