Overview

Location [1]
12p11.23
Protein [2]
Inositol 1,4,5-trisphosphate receptor type 2
Synonyms [1]
ANHD, INSP3R2, IP3R2, CFAP48

ITPR2 is altered in 0.06% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, appendix adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

ITPR2 GENIE Cases - Top Diseases

The most common alterations in ITPR2 are ITPR2-ETV6 Fusion (0.01%) and ITPR2-NRG1 Fusion (0.04%) [3].

ITPR2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.