Location [1]
Protein [2]
Serine/threonine-protein kinase LATS1
Synonyms [1]
wts, WARTS

LATS1 is altered in 1.93% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

LATS1 GENIE Cases - Top Diseases

The most common alterations in LATS1 are LATS1 Amplification (0.16%), LATS1 Loss (0.14%), LATS1 R995C (0.03%), LATS1 R670W (0.02%), and LATS1 R737* (0.03%) [3].

LATS1 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.