Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
1p35.2
Protein [2]
Tyrosine-protein kinase Lck
Synonyms [1]
YT16, LSK, IMD22, p56lck, pp58lck

LCK is altered in 0.10% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, peripheral T-cell lymphoma, not otherwise specified, angioimmunoblastic T-cell lymphoma, endometrial carcinoma, and adenocarcinoma of the gastroesophageal junction having the greatest prevalence of alterations [3].

LCK GENIE Cases - Top Diseases

The most common alterations in LCK are LCK Mutation (0.43%), LCK Loss (0.12%), LCK A367fs (0.02%), LCK A386T (0.02%), and LCK E393K (0.26%) [3].

LCK GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.