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LMNA

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Associated Diseases

Overview

Location [1]
1q22
Protein [2]
Lamin-A/C
Synonyms [1]
CDDC, PRO1, FPL, CMT2B1, HGPS, LGMD1B, CDCD1, LFP, EMD2, FPLD, MADA, CMD1A, IDC, LMNC, LMNL1, LMN1, FPLD2, LDP1

LMNA is altered in 0.05% of all cancers with colon adenocarcinoma, sarcoma, NOS, gallbladder carcinoma, breast invasive ductal carcinoma, and appendix mucinous adenocarcinoma having the greatest prevalence of alterations [3].

LMNA GENIE Cases - Top Diseases

The most common alterations in LMNA are LMNA-NTRK1 Fusion (0.05%), LMNA-CCNE1 Fusion (0.00%), and LMNA-SOCS1 Fusion (0.01%) [3].

LMNA GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.