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LRIG3

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Associated Diseases

Overview

Location [1]
12q14.1
Protein [2]
Leucine-rich repeats and immunoglobulin-like domains protein 3
Synonyms [1]
LIG3

LRIG3 is altered in 0.08% of all cancers with lung adenocarcinoma, pancreatic adenocarcinoma, dedifferentiated liposarcoma, breast invasive ductal carcinoma, and cholangiocarcinoma having the greatest prevalence of alterations [3].

LRIG3 GENIE Cases - Top Diseases

The most common alterations in LRIG3 are LRIG3-ROS1 Fusion (0.05%), LRIG3 Mutation (4.56%), LRIG3 S897N (0.61%), LRIG3 A678T (0.30%), and LRIG3 F464S (0.30%) [3].

LRIG3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.