Location [1]
Protein [2]
Leukocyte tyrosine kinase receptor
Synonyms [1]

Leukocyte receptor tyrosine kinase (LTK) is a gene that encodes a protein that is a member of the ros/insulin receptor family of tyrosine kinases. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as skin cancer, colon cancer, and endometrial cancer.

LTK is altered in 2.43% of all cancers with breast invasive ductal carcinoma, prostate adenocarcinoma, pancreatic adenocarcinoma, adenocarcinoma of unknown primary, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

LTK GENIE Cases - Top Diseases

The most common alterations in LTK are LTK G269A (0.34%), LTK F218I (0.28%), LTK N257T (0.53%), LTK A13fs (2.08%), and LTK A214fs (0.22%) [3].

LTK GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.