Biomarkers /

MAP3K3

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Overview

Location [1]
17q23.3
Protein [2]
Mitogen-activated protein kinase kinase kinase 3
Synonyms [1]
MEKK3, MAPKKK3

MAP3K3 is altered in 0.02% of all cancers with endometrial endometrioid adenocarcinoma, adenocarcinoma of unknown primary, esophageal adenocarcinoma, and extramammary Paget disease having the greatest prevalence of alterations [3].

MAP3K3 GENIE Cases - Top Diseases

The most common alterations in MAP3K3 are MAP3K3-CDK12 Fusion (0.01%), MAP3K3-EME1 Fusion (0.02%), MAP3K3-RARA Fusion (0.00%), and MAP3K3-RPTOR Fusion (0.00%) [3].

MAP3K3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.