Biomarkers /

MAPK8

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Overview

Location [1]
10q11.22
Protein [2]
Mitogen-activated protein kinase 8
Synonyms [1]
JNK-46, PRKM8, SAPK1c, JNK1, SAPK1, JNK, JNK1A2, JNK21B1/2

MAPK8 is altered in 0.45% of all cancers with cervical squamous cell carcinoma, colon adenocarcinoma, colorectal adenocarcinoma, endometrial endometrioid adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

MAPK8 GENIE Cases - Top Diseases

The most common alterations in MAPK8 are MAPK8 Mutation (0.45%), MAPK8 S394P (0.77%), MAPK8 V383M (0.77%), MAPK8 V399M (0.77%), and MAPK8 A419S (0.39%) [3].

MAPK8 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.