Location [1]
Protein [2]
Methyl-CpG-binding domain protein 4
Synonyms [1]

MBD4 is altered in 1.54% of all cancers with colon adenocarcinoma, melanoma, lung adenocarcinoma, breast invasive ductal carcinoma, and glioblastoma having the greatest prevalence of alterations [3].

MBD4 GENIE Cases - Top Diseases

The most common alterations in MBD4 are MBD4 A70T (0.08%), MBD4 V228L (0.06%), MBD4 K518R (0.06%), MBD4 X471_splice (0.06%), and MBD4 Fusion (0.03%) [3].

MBD4 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.