Overview

Location [1]
2p24.3
Protein [2]
N-myc proto-oncogene protein
Synonyms [1]
N-myc, bHLHe37, NMYC, ODED, MODED

The v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) gene encodes a protein located in the nucleus. The protein dimerizes with a co-protein to bind DNA. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

MYCN is altered in 1.39% of all cancers with colon adenocarcinoma, neuroblastoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

MYCN GENIE Cases - Top Diseases

The most common alterations in MYCN are MYCN Mutation (1.00%), MYCN Amplification (0.43%), MYCN P44L (0.10%), MYCN P45fs (0.05%), and MYCN E47fs (0.02%) [3].

MYCN GENIE Cases - Top Alterations

Significance of MYCN in Diseases

Neuroblastoma +

Medulloblastoma +

Malignant Solid Tumor +

Medulloblastoma, Non-WNT/Non-SHH +

Ependymoma +

Soft Tissue Sarcoma +

Desmoplastic Small Round Cell Tumor +

Melanoma +

Central Nervous System Embryonal Neoplasm +

Malignant Glioma +

Osteosarcoma +

Atypical Teratoid/Rhabdoid Tumor +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Desmoplastic/Nodular Medulloblastoma +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Ganglioneuroblastoma +

Large Cell/Anaplastic Medulloblastoma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Alveolar Rhabdomyosarcoma +

Kidney Wilms Tumor +

Wilms Tumor +

High-Grade Glioma, NOS +

Anaplastic Astrocytoma +

Glioblastoma +

Diffuse Glioma +

Glioma +

Retinoblastoma +

Germ Cell Tumor +

Central Nervous System Neoplasm +

Undifferentiated Pleomorphic Sarcoma +

Anaplastic Oligodendroglioma +

Diffuse Large B-Cell Lymphoma +

Mantle Cell Lymphoma +

Small Cell Lung Carcinoma +

Fibrosarcoma +

Leiomyosarcoma +

Lymphoma +

Mature B-Cell Non-Hodgkin Lymphoma +

Meningioma +

Follicular Lymphoma +

Liposarcoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Burkitt Lymphoma +

Central Nervous System Lymphoma +

Childhood Central Nervous System Embryonal Carcinoma +

Choroid Plexus Neoplasm +

Craniopharyngioma +

Diffuse Intrinsic Pontine Glioma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Double-Hit Lymphoma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Ependymoma, RELA Fusion-Positive +

Ewing Sarcoma +

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Of Bone +

Ganglioneuroblastoma, Intermixed +

Ganglioneuroblastoma, Nodular +

Hodgkin Lymphoma +

Intracranial Primitive Neuroectodermal Neoplasm +

NUT Midline Carcinoma Of The Head And Neck +

Neuroectodermal Tumor Of Soft Tissue +

Peripheral T-Cell Lymphoma +

Pineoblastoma +

Rhabdoid Tumor +

Spindle Cell Sarcoma +

Synovial Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.