Myosin XVIIIA (MYO18A) is a gene that encodes a protein that functions in Golgi processes, such as linking Golgi membranes to the cytoskeleton. The protein may also be important in the tensile force required for the budding of vesicles from the Golgi. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as peritoneal cancer, pituitary cancer, and skin cancer.
MYO18A is altered in 0.27% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, pancreatic adenocarcinoma, and glioblastoma having the greatest prevalence of alterations .
The most common alterations in MYO18A are MYO18A-FGFR1 Fusion (0.22%), MYO18A A647V (0.17%), MYO18A G88D (0.17%), MYO18A A1474V (0.08%), and MYO18A A1781T (0.08%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.