Biomarkers /

NEGR1

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Overview

Location [1]
1p31.1
Protein [2]
Neuronal growth regulator 1
Synonyms [1]
Ntra, IGLON4, KILON, DMML2433

NEGR1 is altered in 1.01% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

NEGR1 GENIE Cases - Top Diseases

The most common alterations in NEGR1 are NEGR1 Loss (0.08%), NEGR1 Amplification (0.04%), NEGR1 E229K (0.02%), NEGR1 G270E (0.01%), and NEGR1 P251L (0.01%) [3].

NEGR1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.