Biomarkers /

NPRL2

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Associated Diseases

Overview

Location [1]
3p21.31
Protein [2]
GATOR complex protein NPRL2
Synonyms [1]
TUSC4, FFEVF2, NPR2, NPR2L

NPRL2 is altered in 0.76% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, pancreatic neuroendocrine neoplasm, and adenocarcinoma of unknown primary having the greatest prevalence of alterations [3].

NPRL2 GENIE Cases - Top Diseases

The most common alterations in NPRL2 are NPRL2 Loss (0.05%), NPRL2 R279Q (0.04%), NPRL2 F184L (0.02%), NPRL2 G86R (0.02%), and NPRL2 I160T (0.02%) [3].

NPRL2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.