Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
1p13.2
Pathway
MAP kinase signaling
Protein [2]
GTPase NRas
Synonyms [1]
NRAS1, NS6, ALPS4, NCMS, N-ras, CMNS

NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog) encodes for the GTPase NRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. NRAS is implicated in the pathogenesis of several cancers (for review see PMID: 17384584).

NRAS is altered in 2.90% of all cancers with melanoma, colorectal adenocarcinoma, leukemia, thyroid gland neoplasm, and non-small cell lung carcinoma having the greatest prevalence of alterations [3].

NRAS GENIE Cases - Top Diseases

The most common alterations in NRAS are NRAS Mutation (3.80%), NRAS Mutation (germline) (3.80%), NRAS Mutation (somatic) (3.80%), NRAS Codon 61 Missense (2.33%), and NRAS Q61R (1.06%) [3].

NRAS GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of NRAS in Diseases

Malignant Solid Tumor +

Colorectal Carcinoma +

Melanoma +

Non-Small Cell Lung Carcinoma +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Multiple Myeloma +

Chronic Myelomonocytic Leukemia +

Non-Hodgkin Lymphoma +

Acute Lymphoblastic Leukemia +

Glioma +

Ovarian Carcinoma +

Colorectal Adenocarcinoma +

Cancer +

Pancreatic Carcinoma +

Neurofibromatosis Type 1 +

Pancreatic Ductal Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Lymphoma +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Neuroblastoma +

Breast Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Thyroid Gland Adenocarcinoma +

Thyroid Gland Follicular Carcinoma +

Thyroid Gland Carcinoma +

Rhabdomyosarcoma +

Thyroid Gland Papillary Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Rectal Carcinoma +

Colon Carcinoma +

Malignant Peripheral Nerve Sheath Tumor +

Endometrial Carcinoma +

Soft Tissue Sarcoma +

Sarcoma +

Chronic Myeloid Leukemia +

Bladder Carcinoma +

Head And Neck Carcinoma +

Thymic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Glioblastoma +

Diffuse Large B-Cell Lymphoma +

Anaplastic Astrocytoma +

Hepatocellular Carcinoma +

Prostate Carcinoma +

Renal Cell Carcinoma +

Double-Hit Lymphoma +

Gastric Adenocarcinoma +

Juvenile Myelomonocytic Leukemia +

Mantle Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Peripheral T-Cell Lymphoma +

Refractory Anemia With Excess Blasts +

Refractory Anemia With Excess Blasts-2 +

Rhabdoid Tumor +

Schwannoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.