Biomarkers /

PAXIP1

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Associated Diseases

Overview

Location [1]
7q36.2
Protein [2]
PAX-interacting protein 1
Synonyms [1]
PAXIP1L, PTIP, TNRC2, CAGF29, CAGF28, PACIP1

PAXIP1 is altered in 0.48% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

PAXIP1 GENIE Cases - Top Diseases

The most common alterations in PAXIP1 are PAXIP1 S322C (0.10%), PAXIP1 K907N (0.04%), PAXIP1 F123Y (0.03%), PAXIP1 Loss (0.03%), and PAXIP1 R309Q (0.05%) [3].

PAXIP1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.