Associated Genetic Biomarkers
Programmed cell death 1 ligand 2 (PDCD1LG2; also known as PDL2) is a gene that encodes a protein that functions in the costimulatory signal that is required for T-cell proliferation and IFNG production. The interaction of the protein with PDCD1 blocks T-cell proliferation. Fusions, missense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
PDCD1LG2 is altered in 0.83% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, bladder urothelial carcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in PDCD1LG2 are PDCD1LG2 Amplification (0.29%), PDCD1LG2 Loss (0.25%), PDCD1LG2 P81S (0.08%), PDCD1LG2 Q144L (0.04%), and PDCD1LG2 X273_splice (0.16%) .
PDCD1LG2 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains PDCD1LG2 status as an inclusion criterion, 1 is phase 2 (1 open).
Trials with PDCD1LG2 status in the inclusion eligibility criteria most commonly target invasive breast carcinoma .
The most frequent alteration to serve as an inclusion eligibility criterion is PDCD1LG2 Expression .
Cemiplimab, cyclophosphamide, doxorubicin, and paclitaxel are the most frequent therapies in trials with PDCD1LG2 as an inclusion criteria .
Significance of PDCD1LG2 in Diseases
Invasive Breast Carcinoma +
PDCD1LG2 is altered in 0.93% of invasive breast carcinoma patients .
PDCD1LG2 is an inclusion criterion in 1 clinical trial for invasive breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains PDCD1LG2 status and invasive breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.